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1950 1
1954 1
1956 1
1957 1
1961 1
1962 1
1963 2
1965 1
1966 1
1967 1
1968 6
1970 3
1971 1
1972 1
1973 7
1974 5
1975 13
1976 9
1977 15
1978 19
1979 26
1980 22
1981 18
1982 32
1983 34
1984 53
1985 67
1986 82
1987 113
1988 116
1989 167
1990 159
1991 193
1992 227
1993 219
1994 266
1995 255
1996 315
1997 294
1998 271
1999 255
2000 287
2001 273
2002 323
2003 322
2004 360
2005 381
2006 449
2007 354
2008 371
2009 390
2010 475
2011 450
2012 492
2013 531
2014 525
2015 531
2016 540
2017 564
2018 668
2019 690
2020 812
2021 846
2022 788
2023 792
2024 323

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14,477 results

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Page 1
Review on Alzheimer's disease: Inhibition of amyloid beta and tau tangle formation.
Ashrafian H, Zadeh EH, Khan RH. Ashrafian H, et al. Int J Biol Macromol. 2021 Jan 15;167:382-394. doi: 10.1016/j.ijbiomac.2020.11.192. Epub 2020 Dec 2. Int J Biol Macromol. 2021. PMID: 33278431 Review.
Although the exact sources of the disease are not understood, is it believed that aggregation of amyloid-beta (Abeta) outside of neuron cells and tau aggregation or neurofibrillary tangles (NFTs) formation inside the cell may play crucial roles. In this paper, we are going …
Although the exact sources of the disease are not understood, is it believed that aggregation of amyloid-beta (Abeta) outside of neuron cell …
The last tangle of tau.
Ding H, Johnson GV. Ding H, et al. J Alzheimers Dis. 2008 Aug;14(4):441-7. doi: 10.3233/jad-2008-14413. J Alzheimers Dis. 2008. PMID: 18688096 Free PMC article. Review.
Tau aggregates into neurofibrillary tangles in Alzheimer's disease and tauopathies. There is ongoing debate about whether tau aggregation is toxic and which form of tau is toxic. Based on recent studies showing that mature tau tangles can be dissociated from neurona …
Tau aggregates into neurofibrillary tangles in Alzheimer's disease and tauopathies. There is ongoing debate about whether tau aggrega …
Exercise suppresses neuroinflammation for alleviating Alzheimer's disease.
Wang M, Zhang H, Liang J, Huang J, Chen N. Wang M, et al. J Neuroinflammation. 2023 Mar 19;20(1):76. doi: 10.1186/s12974-023-02753-6. J Neuroinflammation. 2023. PMID: 36935511 Free PMC article. Review.
Alzheimer's disease (AD) is a chronic neurodegenerative disease, with the characteristics of neurofibrillary tangle (NFT) and senile plaque (SP) formation. Although great progresses have been made in clinical trials based on relevant hypotheses, these studies are also acco …
Alzheimer's disease (AD) is a chronic neurodegenerative disease, with the characteristics of neurofibrillary tangle (NFT) and senile …
Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research.
Moloney CM, Lowe VJ, Murray ME. Moloney CM, et al. Alzheimers Dement. 2021 Sep;17(9):1554-1574. doi: 10.1002/alz.12321. Epub 2021 Apr 2. Alzheimers Dement. 2021. PMID: 33797838 Free PMC article. Review.
As neurofibrillary tangles mature, the biology of the neuron undergoes extensive changes that may impact biomarker recognition and therapeutic targeting. Neurofibrillary tangle maturity encompasses three levels: pretangles, mature tangles, and ghost tangle …
As neurofibrillary tangles mature, the biology of the neuron undergoes extensive changes that may impact biomarker recognition and th …
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.
Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM. Yoshiyama Y, et al. Neuron. 2007 Feb 1;53(3):337-51. doi: 10.1016/j.neuron.2007.01.010. Neuron. 2007. PMID: 17270732 Free article.
Remarkably, hippocampal synapse loss and impaired synaptic function were detected in 3 month old P301S Tg mice before fibrillary tau tangles emerged. Prominent microglial activation also preceded tangle formation. ...
Remarkably, hippocampal synapse loss and impaired synaptic function were detected in 3 month old P301S Tg mice before fibrillary tau tang …
[Senile Dementia of the Neurofibrillary Tangle Type (SD-NFT)].
Yamada M. Yamada M. Brain Nerve. 2018 May;70(5):533-541. doi: 10.11477/mf.1416201035. Brain Nerve. 2018. PMID: 29760290 Review. Japanese.
A subset of older individuals with dementia have neurofibrillary tangles (NFTs) in the medial temporal lobe and show absence of amyloid beta-protein (Abeta) deposition in the brain. ...
A subset of older individuals with dementia have neurofibrillary tangles (NFTs) in the medial temporal lobe and show absence of amylo …
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Oddo S, et al. Neuron. 2003 Jul 31;39(3):409-21. doi: 10.1016/s0896-6273(03)00434-3. Neuron. 2003. PMID: 12895417 Free article.
Rather than crossing independent lines, we microinjected two transgenes into single-cell embryos from homozygous PS1(M146V) knockin mice, generating mice with the same genetic background. 3xTg-AD mice progressively develop plaques and tangles. Synaptic dysfunction, includi …
Rather than crossing independent lines, we microinjected two transgenes into single-cell embryos from homozygous PS1(M146V) knockin mice, ge …
Use of Zebrafish Genetic Models to Study Etiology of the Amyloid-Beta and Neurofibrillary Tangle Pathways in Alzheimer's Disease.
Kiper K, Freeman JL. Kiper K, et al. Curr Neuropharmacol. 2022 Mar 4;20(3):524-539. doi: 10.2174/1570159X19666210524155944. Curr Neuropharmacol. 2022. PMID: 34030617 Free PMC article. Review.
While wild-type zebrafish appear to lack some of the neuropathological features of Alzheimer's disease, the advent of genetic editing technologies has expanded the evaluation of the amyloid and neurofibrillary tangle hypotheses using the zebrafish and exploration of pharma …
While wild-type zebrafish appear to lack some of the neuropathological features of Alzheimer's disease, the advent of genetic editing techno …
Along the way to a neurofibrillary tangle: a look at the structure of tau.
Kosik KS, Kowall NW, McKee A. Kosik KS, et al. Ann Med. 1989;21(2):109-12. doi: 10.3109/07853898909149195. Ann Med. 1989. PMID: 2504256 Review.
We report our ongoing work to characterize the molecular nature of neurofibrillary tangles (NFT). An epitope map of tau protein using monoclonal antibodies that crossreact with NFT reveals the presence of epitopes that span the entire tau molecule from the amino terminus t …
We report our ongoing work to characterize the molecular nature of neurofibrillary tangles (NFT). An epitope map of tau protein using …
Neurofibrillary tangle parkinsonian disorders--tau pathology and tau genetics.
Morris HR, Lees AJ, Wood NW. Morris HR, et al. Mov Disord. 1999 Sep;14(5):731-6. doi: 10.1002/1531-8257(199909)14:5<731::aid-mds1004>3.0.co;2-j. Mov Disord. 1999. PMID: 10495033 Review.
A number of related conditions, including progressive supranuclear palsy (PSP), corticobasal degeneration, Pick's disease, and the parkinsonism dementia complex of Guam, are characterized by the deposition of tau neurofibrillary tangles in the absence of amyloid pathology. …
A number of related conditions, including progressive supranuclear palsy (PSP), corticobasal degeneration, Pick's disease, and the parkinson …
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